Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 306
  • Home
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 2  |  Page : 93-99

Neutrophil equanimity: Function in health and diseases in periodontium


Department of Periodontics, Himachal Dental College, Sundernagar, Himachal Pradesh, India

Correspondence Address:
Dr. Komal Fanda
Department of Periodontics, Himachal Dental College, Sundernagar - 175 002, Himachal Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sidj.sidj_27_20

Rights and Permissions

The oral cavity is a distinct space where the microbiota is continually changing from the mechanical effort of eating and the incursion of foreign microorganisms such as bacteria, fungi, and viruses. There is a balance between symbiotic bacteria and the innate immune system in healthy gingival tissues, which is mainly maintained by neutrophils. Neutrophils are the essential killers of the body and have been recognized for a long time. However, rather than accurate snipers, neutrophils are often seen as crude and unrefined legionnaires, whose successful missions are usually liable for significant collateral damage. The excess of microorganisms in the biofilm creates an inflammatory state that leads to the recruitment of more immune cells, in which mainly neutrophils can be detected. However, the microbial pathogens within the gingival crevice cannot be abolished or controlled by neutrophils. Sometimes, neutrophil accumulation, rather than protecting and favoring periodontal tissue, can lead to a chronic inflammatory disease that can destroy the tooth-supporting tissues or the periodontium. Thus, it is imperative to maintain homeostasis between neutrophil function and microbe challenge to ensure periodontal health. This critical review article aims to discuss and outline the morphology of neutrophil function in periodontal inflammation, including neutrophils' action on biofilm and neutrophil dysfunction to prevent various syndromes related to it and its myriad potential novel therapeutic measures.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed442    
    Printed8    
    Emailed0    
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal